Oral and intravenous pharmacokinetics of 5-fluoro-2′-deoxycytidine and THU in cynomolgus monkeys and humans

Author:

Holleran Julianne L.,Beumer Jan H.,McCormick David L.,Johnson William D.,Newman Edward M.,Doroshow James H.,Kummar Shivaani,Covey Joseph M.,Davis Myrtle,Eiseman Julie L.

Funder

National Cancer Institute

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference17 articles.

1. Mekras JA, Boothman DA, Perez LM, Greer S (1984) Use of 5-fluorodeoxycytidine and tetrahydrouridine to exploit high levels of deoxycytidylate deaminase in tumors to achieve DNA- and target-directed therapies. Cancer Res 44(6):2551–2560

2. Boothman DA, Briggle TV, Greer S (1987) Tumor-selective metabolism of 5-fluoro-2’-deoxycytidine coadministered with tetrahydrouridine compared to 5-fluorouracil in mice bearing Lewis lung carcinoma. Cancer Res 47(9):2354–2362

3. Boothman DA, Briggle TV, Greer S (1987) Protective, tumor-selective dual pathway activation of 5-fluoro-2’-deoxycytidine provided by tetrahydrouridine in mice bearing mammary adenocarcinoma-755. Cancer Res 47(9):2344–2353

4. Kaysen J, Spriggs D, Kufe D (1986) Incorporation of 5-fluorodeoxycytidine and metabolites into nucleic acids of human MCF-7 breast carcinoma cells. Cancer Res 46(9):4534–4538

5. Smith SS, Kaplan BE, Sowers LC, Newman EM (1992) Mechanism of human methyl-directed DNA methyltransferase and the fidelity of cytosine methylation. Proc Natl Acad Sci USA 89(10):4744–4748

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