In-Line Vis-NIR Spectral Analysis for the Column Chromatographic Processes of the Ginkgo biloba L. Leaves. Part II: Batch-to-Batch Consistency Evaluation of the Elution Process
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Published:2022-11-18
Issue:11
Volume:9
Page:378
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ISSN:2297-8739
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Container-title:Separations
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language:en
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Short-container-title:Separations
Author:
Li Wenlong,Wang Xi,Chen Houliu,Yan Xu,Qu Haibin
Abstract
An in-line monitoring method for the elution process of Ginkgo biloba L. leaves using visible and near-infrared spectroscopy in conjunction with multivariate statistical process control (MSPC) was established. Experiments, including normal operating batches and abnormal ones, were designed and carried out. The MSPC model for the elution process was developed and validated. The abnormalities were detected successfully by the control charts of principal component scores, Hotelling T2, or DModX (distance to the model). The results suggested that the established method can be used for the in-line monitoring and batch-to-batch consistency evaluation of the elution process.
Funder
the Key R & D Project of the Zhejiang Science and Technology Program
Hebei Industrial Innovation and Entrepreneurship Team
Wuhan Science and Technology Project
the Key Project from National Project for Standardization of Chinese Materia Medica
the National S&T Major Project of China
Subject
Filtration and Separation,Analytical Chemistry
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