Optimization of Steam Distillation Process for Volatile Oils from Forsythia suspensa and Lonicera japonica according to the Concept of Quality by Design
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Published:2023-01-01
Issue:1
Volume:10
Page:25
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ISSN:2297-8739
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Container-title:Separations
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language:en
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Short-container-title:Separations
Author:
Chen Xinying,
Guo Dongyun,
Gong XingchuORCID,
Wan Na,
Wu ZhenfengORCID
Abstract
In this study, the process of steam distillation to collect volatile oils from Forsythia suspensa (F. suspensa) and Lonicera japonica (L. japonica) was optimized according to the concept of quality by design. First, the liquid/material ratio, distillation time, and collection temperature were identified as critical process parameters by a review of the literature and single-factor experiments. Then, a Box–Behnken design was used to study the quantitative relationship between the three process parameters, two raw material properties, and the yield of volatile oil. A mathematical model was established with an R2 value exceeding 0.90. Furthermore, the design space of the volatile oil yield was calculated by a probability-based method. The results of a verification experiment showed that the model was accurate and the design space was reliable. A total of 16 chemical constituents were identified in the volatile oil from mixtures of F. suspensa and L. japonica. The content of β-pinene was the highest (54.75%), and the composition was similar to that of the volatile oil of F. suspensa. The results showed that when F. suspensa and L. japonica were distilled together, the main contribution to the volatile oil was from F. suspensa. The volatile oil yield from the combination of F. suspensa and L. japonica was not higher than that from L. japonica.
Funder
National Natural Science Foundation of China
Open Project of State Key Laboratory of Innovative Medicine and High Efficiency and Energy Saving Pharmaceutical Equipment in Jiangxi University of Chinese Medicine
Provincial College Students Innovation and Entrepreneurship Program
Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine
Jiangxi Traditional Chinese Medicine Research Program
Subject
Filtration and Separation,Analytical Chemistry
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