4-[Bis(thiazol-2-ylamino)methyl]phenol

Abstract

We have designed and synthesized novel bis-thiazole derivative. A 4-[bis(thiazol-2-ylamino)methyl]phenol was efficiently prepared in 71% yield by the reaction of 2-aminothiazole with 4-hydroxybenzaldehyde in ethanol for 24 h. The structure of newly obtained compound was characterized by 1H, 13C NMR and mass spectrometry. Bis-thiazole derivative exhibits high tyrosinase inhibitory activity with an IC50 value of 29.71 μM. This inhibitory activity is 2.4 times higher than that of activity of kojic acid (IC50 72.27 µM) and almost 13 times higher than that of ascorbic acid (IC50 385.6 µM). Obtained data suggest that the presented compound may be a leading candidate for a tyrosinase inhibitor.