Synthesis, Crystal Structure and Anti-Leukemic Activity of (E)-Pyrrolo[1,2-a]quinoxalin-4-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one-Reference-Cited by-同舟云学术

Synthesis, Crystal Structure and Anti-Leukemic Activity of (E)-Pyrrolo[1,2-a]quinoxalin-4-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

Published:2023-07-08 Issue:3 Volume:2023 Page:M1691
ISSN:1422-8599
Container-title:Molbank
language:en
Short-container-title:Molbank

Author:

Guillon Jean¹^ORCID,Savrimoutou Solène¹,Albenque-Rubio Sandra¹,Pinaud Noël²^ORCID,Fillová Nina¹,Moreau Stéphane¹,Baylot Virginie³,Desplat Vanessa⁴

Affiliation:

1. Faculty of Pharmacy, University of Bordeaux, CNRS, INSERM, ARNA, UMR 5320, U1212, 146 Rue Léo Saignat, F-33076 Bordeaux, France

2. ISM, University of Bordeaux, CNRS UMR 5255, 351 Cours de la Liberation, F-33405 Talence, France

3. Centre de Recherche en Cancérologie de Marseille (CRCM), Institut Paoli-Calmettes, University of Aix Marseille, CNRS UMR 7258, Inserm U1068, 27 Bd Lei Roure, F-13009 Marseille, France

4. Faculty of Pharmacy, University of Bordeaux, INSERM U1312, BRIC, 146 Rue Léo Saignat, F-33076 Bordeaux, France

Abstract

(E)-Pyrrolo[1,2-a]quinoxalin-4-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one was designed then synthesized using a multi-step pathway starting from commercially available 2-nitroaniline. Structure characterization of this original substituted pyrrolo[1,2-a]quinoxaline compound was achieved by using FT-IR, 1H-NMR, 13C-NMR, X-Ray and HRMS spectral analysis. This new pyrroloquinoxaline shows interesting cytotoxic potential against different human leukemia cell lines (MV4-11, K562, MOLM14 and Jurkat cells).

Publisher

MDPI AG

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://www.mdpi.com/1422-8599/2023/3/M1691/pdf

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