Vinylation of N-Heteroarenes through Addition/Elimination Reactions of Vinyl Selenones-Reference-Cited by-同舟云学术

Vinylation of N-Heteroarenes through Addition/Elimination Reactions of Vinyl Selenones

Published:2023-08-12 Issue:16 Volume:28 Page:6026
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Palomba Martina¹,Dias Italo Franco Coelho¹,Cocchioni Michelangelo¹,Marini Francesca¹^ORCID,Santi Claudio¹^ORCID,Bagnoli Luana¹^ORCID

Affiliation:

1. Group of Catalysis, Synthesis and Organic Green Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1, 06123 Perugia, Italy

Abstract

A new protocol for the synthesis of N-vinyl azoles using vinyl selenones and azoles in the presence of potassium hydroxide was developed. This reaction proceeded under mild and transition metal-free conditions through an addition/elimination cascade process. Both aromatic and aliphatic vinyl selenones and various mono-, bi- and tri-cyclic azoles can be tolerated and give terminal N-vinyl azoles in moderate to high yields. A plausible mechanism is also proposed.

Funder

University of Perugia “Fondo per la Ricerca di Base”

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/16/6026/pdf

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