Iodine/Oxone® oxidative system for the synthesis of selenylindoles bearing a benzenesulfonamide moiety as carbonic anhydrase I, II, IX, and XII inhibitors-Reference-Cited by-同舟云学术

Iodine/Oxone® oxidative system for the synthesis of selenylindoles bearing a benzenesulfonamide moiety as carbonic anhydrase I, II, IX, and XII inhibitors

Published:2024 Issue:32 Volume:22 Page:6532-6542
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Palomba Martina¹,Angeli Andrea²,Galdini Riccardo¹,Hughineata Alexandra Joana¹,Perin Gelson³,Lenardão Eder João³^ORCID,Marini Francesca¹^ORCID,Santi Claudio¹^ORCID,Supuran Claudiu T.²^ORCID,Bagnoli Luana¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences (Group of Catalysis, Synthesis and Organic Green Chemistry), University of Perugia, Via del Liceo, 1-06123 Perugia, Italy

2. University of Florence, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy

3. Laboratório de Síntese Orgânica Limpa (LASOL), Centro de Ciências Químicas, Farmacêuticas e de Alimentos (CCQFA), Universidade Federal de Pelotas (UFPel), P.O. Box 354, CEP: 96010-900 Pelotas, RS, Brazil

Abstract

An eco-friendly approach that uses Oxone as the oxidant and iodine as the catalyst generates 3-selenelylindoles. Novel derivatives containing a benzenesulfonamide moiety were tested as human carbonic anhydrase I, II, IX and XII inhibitors.

Funder

Università degli Studi di Perugia

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00826J

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