Koninginins X-Z, Three New Polyketides from Trichoderma koningiopsis SC-5-Reference-Cited by-同舟云学术

Koninginins X-Z, Three New Polyketides from Trichoderma koningiopsis SC-5

Published:2023-11-29 Issue:23 Volume:28 Page:7848
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Peng Weiwei¹²,Tan Jianbing¹²,Sang Zihuan¹²³,Huang Yuantao⁴,Xu Li¹²,Zheng Yuting¹²,Qin Siyu¹²,Tan Haibo¹²³,Zou Zhenxing¹²

Affiliation:

1. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China

2. Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Changsha 410013, China

3. Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510520, China

4. Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University, Haikou 570208, China

Abstract

Koninginins X-Z (1–3), three novel polyketides, were isolated from the solid fermentation of the endophytic fungus Trichoderma koningiopsis SC-5. Their structures, including the absolute configurations, were comprehensively characterized by a combination of NMR spectroscopic methods, HRESIMS, 13C NMR, DFT GIAO 13C NMR, and electronic circular dichroism calculations as well as single crystal X-ray diffraction. In addition, all the compounds were evaluated for antifungal activity against Candida albicans.

Funder

National Natural Science Foundation of China

Youth Innovation Promotion Association of CAS

Natural Science Foundation of Guangdong Province

Natural Science Foundation of Hunan Province

Key Research and Development Project of Hainan Province

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/23/7848/pdf

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