Research Progress on Natural Plant Molecules in Regulating the Blood–Brain Barrier in Alzheimer’s Disease
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Published:2023-11-16
Issue:22
Volume:28
Page:7631
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ISSN:1420-3049
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Container-title:Molecules
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language:en
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Short-container-title:Molecules
Author:
Wu Weidong1, Huang Jiahao2, Han Pengfei3, Zhang Jian1, Wang Yuxin1, Jin Fangfang4, Zhou Yanyan1
Affiliation:
1. Basic Theory of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, China 2. Department of Chinese Pharmacology, Heilongjiang University of Chinese Medicine, Harbin 150040, China 3. Science and Education Section, Zhangjiakou First Hospital, Zhangjiakou 075041, China 4. Department of Internal Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, China
Abstract
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder. With the aging population and the continuous development of risk factors associated with AD, it will impose a significant burden on individuals, families, and society. Currently, commonly used therapeutic drugs such as Cholinesterase inhibitors, N-methyl-D-aspartate antagonists, and multiple AD pathology removal drugs have been shown to have beneficial effects on certain pathological conditions of AD. However, their clinical efficacy is minimal and they are associated with certain adverse reactions. Furthermore, the underlying pathological mechanism of AD remains unclear, posing a challenge for drug development. In contrast, natural plant molecules, widely available, offer multiple targeting pathways and demonstrate inherent advantages in modifying the typical pathologic features of AD by influencing the blood–brain barrier (BBB). We provide a comprehensive review of recent in vivo and in vitro studies on natural plant molecules that impact the BBB in the treatment of AD. Additionally, we analyze their specific mechanisms to offer novel insights for the development of safe and effective targeted drugs as well as guidance for experimental research and the clinical application of drugs for the prevention and treatment of AD.
Funder
National Natural Science Foundation of China Natural Science Foundation of Heilongjiang Province
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
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