The Synthesis and Biological Applications of the 1,2,3-Dithiazole Scaffold-Reference-Cited by-同舟云学术

The Synthesis and Biological Applications of the 1,2,3-Dithiazole Scaffold

Published:2023-04-03 Issue:7 Volume:28 Page:3193
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Kalogirou Andreas S.¹^ORCID,Oh Hans J.²^ORCID,Asquith Christopher R. M.²³^ORCID

Affiliation:

1. Department of Life Sciences, School of Sciences, European University Cyprus, 6 Diogenis Str., Engomi, P.O. Box 22006, Nicosia 1516, Cyprus

2. Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA

3. School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland

Abstract

The 1,2,3-dithiazole is an underappreciated scaffold in medicinal chemistry despite possessing a wide variety of nascent pharmacological activities. The scaffold has a potential wealth of opportunities within these activities and further afield. The 1,2,3-dithiazole scaffold has already been reported as an antifungal, herbicide, antibacterial, anticancer agent, antiviral, antifibrotic, and is a melanin and Arabidopsis gibberellin 2-oxidase inhibitor. These structure activity relationships are discussed in detail, along with insights and future directions. The review also highlights selected synthetic strategies developed towards the 1,2,3-dithiazole scaffold, how these are integrated to accessibility of chemical space, and to the prism of current and future biological activities.

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/7/3193/pdf

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