Potential Benefits of Coffee Consumption on Improving Biomarkers of Oxidative Stress and Inflammation in Healthy Individuals and Those at Increased Risk of Cardiovascular Disease
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Published:2023-09-05
Issue:18
Volume:28
Page:6440
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ISSN:1420-3049
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Container-title:Molecules
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language:en
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Short-container-title:Molecules
Author:
Dludla Phiwayinkosi V.12ORCID, Cirilli Ilenia3ORCID, Marcheggiani Fabio3ORCID, Silvestri Sonia3ORCID, Orlando Patrick3, Muvhulawa Ndivhuwo14ORCID, Moetlediwa Marakiya T.4ORCID, Nkambule Bongani B.5, Mazibuko-Mbeje Sithandiwe E.4, Hlengwa Nokulunga2ORCID, Hanser Sidney6ORCID, Ndwandwe Duduzile1ORCID, Marnewick Jeanine L.7ORCID, Basson Albertus K.2ORCID, Tiano Luca3ORCID
Affiliation:
1. Cochrane South Africa, South African Medical Research Council, Cape Town 7505, South Africa 2. Department of Biochemistry and Microbiology, University of Zululand, Richards Bay 3886, South Africa 3. Department of Life and Environmental Sciences, Polytechnic University of Marche, 60131 Ancona, Italy 4. Department of Biochemistry, North-West University, Mafikeng Campus, Mmabatho 2735, South Africa 5. School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4000, South Africa 6. Department of Physiology and Environmental Health, University of Limpopo, Polokwane 0727, South Africa 7. Applied Microbial and Health Biotechnology Institute, Cape Peninsula University of Technology, Bellville 7535, South Africa
Abstract
Cardiovascular diseases (CVDs) are considered the predominant cause of death globally. An abnormal increase in biomarkers of oxidative stress and inflammation are consistently linked with the development and even progression of metabolic diseases, including enhanced CVD risk. Coffee is considered one of the most consumed beverages in the world, while reviewed evidence regarding its capacity to modulate biomarkers of oxidative stress and inflammation remains limited. The current study made use of prominent electronic databases, including PubMed, Google Scholar, and Scopus to retrieve information from randomized controlled trials reporting on any association between coffee consumption and modulation of biomarkers of oxidative stress and inflammation in healthy individuals or those at increased risk of developing CVD. In fact, summarized evidence indicates that coffee consumption, mainly due to its abundant antioxidant properties, can reduce biomarkers of oxidative stress and inflammation, which can be essential in alleviating the CVD risk in healthy individuals. However, more evidence suggests that regular/prolonged use or long term (>4 weeks) consumption of coffee appeared to be more beneficial in comparison with short-term intake (<4 weeks). These positive effects are also observed in individuals already presenting with increased CVD risk, although such evidence is very limited. The current analysis of data highlights the importance of understanding how coffee consumption can be beneficial in strengthening intracellular antioxidants to alleviate pathological features of oxidative stress and inflammation to reduce CVD risk within the general population. Also covered within the review is essential information on the metabolism and bioavailability profile of coffee, especially caffeine as one of its major bioactive compounds.
Funder
South African Medical Research Council National Research Foundation
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
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