Total Synthesis of Nicrophorusamide A and Structural Disproof of the Proposed Noursamycin A

Abstract

Total synthesis of the proposed noursamycin A has been accomplished, which disproves the original structural assignments. The synthetic strategy described herein has also been employed in the first total synthesis of nicrophorusamide A, a cyclopeptide that is structurally related to noursamycin A.