Neuroinflammation of Microglial Regulation in Alzheimer’s Disease: Therapeutic Approaches

Author:

Chen Haiyun1,Zeng Yuhan2345,Wang Dan2345,Li Yichen6,Xing Jieyu1,Zeng Yuejia1,Liu Zheng7,Zhou Xinhua8,Fan Hui2345

Affiliation:

1. College of Pharmacy, Clinical Pharmacy (School of Integrative Pharmacy), Guangdong Pharmaceutical University, Guangzhou 510006, China

2. Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, China

3. Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, China

4. Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangzhou 510006, China

5. Key Unit of Modulating Liver to Treat Hyperlipemia SATCM, State Administration of Traditional Chinese Medicine, Guangzhou 510006, China

6. Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Zhanjiang 524023, China

7. School of Medicine, Foshan University, Foshan 528000, China

8. Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou 510000, China

Abstract

Alzheimer’s disease (AD) is a complex degenerative disease of the central nervous system that is clinically characterized by a progressive decline in memory and cognitive function. The pathogenesis of AD is intricate and not yet fully understood. Neuroinflammation, particularly microglial activation-mediated neuroinflammation, is believed to play a crucial role in increasing the risk, triggering the onset, and hastening the progression of AD. Modulating microglial activation and regulating microglial energy metabolic disorder are seen as promising strategies to intervene in AD. The application of anti-inflammatory drugs and the targeting of microglia for the prevention and treatment of AD has emerged as a new area of research interest. This article provides a comprehensive review of the role of neuroinflammation of microglial regulation in the development of AD, exploring the connection between microglial energy metabolic disorder, neuroinflammation, and AD development. Additionally, the advancements in anti-inflammatory and microglia-regulating therapies for AD are discussed.

Funder

Natural Science Foundation of Guangdong Province

Science and Technology Program of Guangzhou

Publisher

MDPI AG

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