3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles-Reference-Cited by-同舟云学术

3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles

Published:2021-06-08 Issue:12 Volume:26 Page:3491
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Pan Xinhui,Xin Xiaobing,Mao Ying,Li Xin,Zhao Yanan^ORCID,Liu Yidi,Zhang Ke,Yang Xiaoda,Wang Jinhui

Abstract

In this study, 3-benzoylisoxazolines were synthesized by reacting alkenes with various α-nitroketones using chloramine-T as the base. The scope of α-nitroketones and alkenes is extensive, including different alkenes and alkynes to form various isoxazolines and isoxazoles. The use of chloramine-T, as the low-cost, easily handled, moderate base for 1,3-dipolar cycloaddition is attractive.

Funder

National Science and Technology Major Projects for New Drug Development of China

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/26/12/3491/pdf

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