Affiliation:
1. Key Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, School of Pharmaceutical Sciences, Shihezi University, Shihezi 832002, China
2. Stake Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
Abstract
This article reports in detail a method for the synthesis of 3-benzoxoxazoline by the reaction of alkenes (alkynes) and a variety of α-nitroketones in the presence of p-TsOH. The scope of alkenes is broad, including different alkenes and the alkyne. This reaction provides a convenient and efficient synthetic method of 3-benzoylisoxazolines.
Funder
National Natural Science Foundation of China
The Open Project of Stake Key Laboratory of Natural and Biomimetic Drugs, Peking University
The Open Project of Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education
Youth Innovative Talent Cultivation Projects of Shihezi University
The National Innovation and Entrepreneurship Training Program for Undergraduate
The Open Sharing Fund for the Large-scale Instruments and Equipments of Shihezi University
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science