Abstract
The intestinal absorption of fatty acids, glucose and fructose is part of the basic requirements for the provision of energy in the body. High access of saturated longchain fatty acids (LCFA), glucose and fructose can facilitate the development of metabolic diseases, particularly the metabolic syndrome and type-2 diabetes mellitus (T2DM). Research has been done to find substances which decelerate or inhibit intestinal resorption of these specific food components. Promising targets are the inhibition of intestinal long-chain fatty acid (FATP2, FATP4), glucose (SGLT1, GLUT2) and fructose (GLUT2, GLUT5) transporters by plant extracts and by pure substances. The largest part of active components in plant extracts belongs to the group of polyphenols. This review summarizes the knowledge about binding sites of named transporters and lists the plant extracts which were tested in Caco-2 cells regarding uptake inhibition.
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference171 articles.
1. Dietary Regulation of Glucose Metabolism in Metabolic Syndrome
2. Diabeteshttp://www.who.int/mediacentre/factsheets/fs312/en
3. Infographics on diabeteshttp://www.who.int/diabetes/infographics/en/
4. Top 10 causes of deathhttp://www.who.int/gho/mortality_burden_disease/causes_death/top_10/en/
5. The top 10 causes of deathhttp://www.who.int/mediacentre/factsheets/fs310/en/
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