One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water-Reference-Cited by-同舟云学术

One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water

Published:2019-03-04 Issue:5 Volume:24 Page:893
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Chen Liang,Zhu Huajian,Wang Jiang,Liu Hong

Abstract

A facile and eco-friendly method has been developed for the synthesis of imidazoles and thiazoles from ethylarenes in water. The reaction proceeds via in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant, followed by trapping with suitable nucleophiles to provide the corresponding products in good yields under metal-free conditions.

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/24/5/893/pdf

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