Enantioselective Synthesis of Atropisomers by Oxidative Aromatization with Central-to-Axial Conversion of Chirality-Reference-Cited by-同舟云学术

Enantioselective Synthesis of Atropisomers by Oxidative Aromatization with Central-to-Axial Conversion of Chirality

Published:2023-03-31 Issue:7 Volume:28 Page:3142
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Lemaitre Clément¹,Perulli Stefania²,Quinonero Ophélie¹,Bressy Cyril¹,Rodriguez Jean¹,Constantieux Thierry¹,García Mancheño Olga²^ORCID,Bugaut Xavier¹³

Affiliation:

1. Aix Marseille Univ, CNRS, Centrale Marseille, iSm2, 13397 Marseille, France

2. Organic Chemistry Institute, University of Münster, Corrensstraße 36/40, 48149 Münster, Germany

3. Université de Strasbourg, Université de Haute-Alsace, CNRS, LIMA, UMR 7042, 67000 Strasbourg, France

Abstract

Atropisomers are fascinating objects of study by themselves for chemists but also find applications in various sub-fields of applied chemistry. Obtaining them in enantiopure form is far from being a solved challenge, and the past decades has seen a surge of methodological developments in that direction. Among these strategies, oxidative aromatization with central-to-axial conversion of chirality has gained increasing popularity. It consists of the oxidation of a cyclic non-aromatic precursors into the corresponding aromatic atropisomers. This review proposes a critical analysis of this research field by delineating it and discussing its historical background and its present state of the art to draw potential future development directions.

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/7/3142/pdf

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