Enantioselective Synthesis of Heteroatom‐Linked Non‐Biaryl Atropisomers

Author:

Naghim Abdelati1,Rodriguez Jean1ORCID,Chuzel Olivier1ORCID,Chouraqui Gaëlle1ORCID,Bonne Damien1ORCID

Affiliation:

1. Aix Marseille Université CNRS, Centrale Méditerranée, iSm2 13397 Marseille France

Abstract

AbstractAtropisomers hold significant fascination, not only for their prevalence in natural compounds but also for their biological importance and wide‐ranging applications as chiral materials, ligands, and organocatalysts. While biaryl and heterobiaryl atropisomers are commonly studied, the enantioselective synthesis of less abundant heteroatom‐linked non‐biaryl atropisomers presents a formidable challenge in modern organic synthesis. Unlike classical atropisomers, these molecules allow rotation around two bonds, resulting in low barriers to enantiomerization through concerted bond rotations. In recent years the discovery of new configurationally stable rare non‐biaryl scaffolds such as aryl amines, aryl ethers and aryl sulfones as well as innovative methodologies to control their configuration have been disclosed in the literature and constitute the topic of this minireview.

Publisher

Wiley

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