Abstract
The dichloromethane extract from leaves of Melicope barbigera (Rutaceae), endemic to the Hawaiian island of Kaua’i, yielded four new and three previously known acetophenones and 2H-chromenes, all found for the first time in M. barbigera. The structures of the new compounds obtained from the dichloromethane extract after purification by chromatographic methods were unambiguously elucidated by spectroscopic analyses including 1D/2D NMR spectroscopy and HRESIMS. The absolute configuration was determined by modified Mosher’s method. Compounds 2, 4 and the mixture of 6 and 7 exhibited moderate cytotoxic activities against the human ovarian cancer cell line A2780 with IC50 values of 30.0 and 75.7 µM for 2 and 4, respectively, in a nuclear shrinkage cytotoxicity assay.
Funder
Deutsche Forschungsgemeinschaft
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference76 articles.
1. Historical biogeography ofMelicope(Rutaceae) and its close relatives with a special emphasis on Pacific dispersals
2. On the Taxonomy and Biogeography of Euodia and Melicope (Rutaceae);Hartley;Allertonia,2000
3. Phylogeny of Hawaiian Melicope (Rutaceae): RAD-seq Resolves Species Relationships and Reveals Ancient Introgression
4. Manual of the Flowering Plants of Hawai’i, Vols. 1 and 2;Wagner,1999
5. Possible Extinctions, Rediscoveries, and New Plant Records within the Hawaiian Islands;Wood;Bish. Mus. Occas. Pap.,2012
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献