Affiliation:
1. Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China
2. Department of Pharmacy, Shenyang Medical College, Shenyang 110034, China
Abstract
Natural compounds are rich in pharmacological properties that are a hot topic in pharmaceutical research. The quinoline ring plays important roles in many biological processes in heterocycles. Many pharmacological compounds, including saquinavir and chloroquine, have been marketed as quinoline molecules with good anti-viral and anti-parasitic properties. Therefore, in this review, we summarize the medicinal chemistry of quinoline-modified natural product quinoline derivatives that were developed by several research teams in the past 10 years and find that these compounds have inhibitory effects on bacteria, viruses, parasites, inflammation, cancer, Alzheimer’s disease, and others.
Funder
Educational Department of Liaoning Province
Doctoral Research Foundation of Shenyang Medical College
Higher Education Discipline Innovation Project
National Natural Science Foundation of China
Key Projects of Jilin Province Science and Technology Development
Jilin Scientific and Technological Development Program
Education Department Project of Jilin
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Cited by
10 articles.
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