Affiliation:
1. Department of Traditional Chinese Medicine, College of Traditional Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China
2. Department of Traditional Chinese Medicine, College of Medicine, Changchun Sci-Tech University, Changchun 130600, China
Abstract
The dried bulbs of Allii Macrostemonis Bulbus (AMB) are called “薤白” in China and are mainly distributed in Asia. The plant species included in the 2020 Edition of the Chinese Pharmacopoeia (ChP) are Allium macrostemon Bunge (called xiaogensuan in Chinese, A. macrostemon) and Allium chinense G. Don (called xie in Chinese, A. chinense), respectively. In the traditional Chinese medicine (TCM) theoretical system, AMB is warm in nature, acrid-bitter taste, and attributive to the heart, lung, stomach, large intestine meridian. AMB has the function of activating Yang and removing stasis, regulating Qi and eliminating stagnation. Modern pharmacological studies have shown that AMB has anti-platelet aggregation, hypolipidemic, anti-atherosclerotic, cardiomyocyte, vascular endothelial cell protection, anti-cancer, anti-bacterial, anti-asthmatic, and anti-oxidant effects. In some Asian countries, AMB is often used to treat coronary heart disease (CHD), angina pectoris (AP), asthma, and diarrhea. This review collates the botanical background, ethnopharmacology, phytochemistry, pharmacological activities, quality control, and toxicological studies of AMB, and provides an outlook on the current research deficiencies and future research priorities of AMB, intending to provide ideas for future research directions and commercial development.
Funder
Jilin Science and Technology Development Program Project
Jilin Agricultural University Graduate Teaching Case Library Construction Project
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference177 articles.
1. Chinese Pharmacopoeia Commission (2020). Pharmacopoeia of People’s Republic of China, China Medical Science Press. Part 1.
2. Phytochemistry and pharmacology of Allii Macrostemonis Bulbus, a traditional Chinese medicine;Yao;Chin. J. Nat. Med.,2016
3. Editorial Committee of the Flora of China (2004). Flora of China, Science Press. Available online: http://www.efloras.org/volume_page.aspx?volume_id=2014&flora_id=2.
4. Editorial Committee of the Flora of China (2004). Flora of China, Science Press. Available online: http://flora.huh.harvard.edu/china/mss/volume14/index.htm.
5. Microbial steroid transformations: Current state and prospects;Donova;Appl. Microbiol. Biotechnol.,2012