Effects of the seeds of Allium fistulosum extract on hemodynamics and myocardial oxygen consumption in dogs

Abstract

Abstract Background: The purpose of this study was to evaluate the effects of the seeds of Allium fistulosum extract (SAFE) on hemodynamics and myocardial oxygen consumption in dogs. Method: Dog models were divided into the control group (saline, 2 mL·kg-1), SAFE low-, medium- and high-dose groups (15, 45, and 90 mg·kg-1) and the positive control group (Xingling granule, 300 mg·kg-1). Hemodynamicindices, including heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), left ventricular systolic blood pressure (LVSP), left ventricular end-diastolic blood pressure (LVEDP), maximum and minimum changes rate of left ventricular systolic blood pressure (+dp/dt max, -dp/dt max ), myocardial oxygen consumption, myocardial oxygen uptake rate, coronary blood flow, coronary resistance, cardiac output, and vascular resistance, were observed in the experimental dog models. Results: The results showed that LVEDP, +dp/dt max and -dp/dt max were slightly and temporarily reduced in the low- and medium-dose groups, and the other indices of HR, SBP, DBP, MAP, and LVSP were not significantly affected. The results also showed that SAFE significantly decreased myocardial oxygen consumption and the myocardial oxygen uptake rate, and there were no significant effects on coronary blood flow, coronary resistance, cardiac output, and vascular resistance. Conclusions: SAFE had no significant effect on hemodynamicindices but had significant effects on the prevention of myocardial ischemia.