Structural Modification and Biological Activity of Polysaccharides-Reference-Cited by-同舟云学术

Structural Modification and Biological Activity of Polysaccharides

Published:2023-07-14 Issue:14 Volume:28 Page:5416
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Zhao Ting¹²,Yang Min¹²,Ma Lina¹²,Liu Xinglong¹²,Ding Qiteng²³,Chai Guodong²⁴,Lu Yang²⁴,Wei Hewei²³,Zhang Shuai²³,Ding Chuanbo¹²

Affiliation:

1. College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China

2. Scientific and Technological Innovation Center of Health Products and Medical Materials with Characteristic Resources of Jilin Province, Jilin Agricultural University, Changchun 130118, China

3. College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China

4. College of Resources and Environment, Jilin Agricultural University, Changchun 130118, China

Abstract

Natural polysaccharides are macromolecular substances with a wide range of biological activities. The structural modification of polysaccharides by chemical means can enhance their biological activity. This paper reviews the latest research reports on the chemical modification of natural polysaccharides. At present, the modification methods of polysaccharides mainly include sulfation, phosphorylation, carboxymethylation, socialization, methylation and acetylation. The chemical and physical structures of the modified polysaccharides were detected via ultraviolet spectroscopy, FT-IR, high-performance liquid chromatography, ultraviolet spectroscopy, gas chromatography–mass spectrometry, nuclear magnetic resonance and scanning electron microscopy. Modern pharmacological studies have shown that the modified polysaccharide has various biological activities, such as antioxidant, antitumor, immune regulation, antiviral, antibacterial and anticoagulant functions in vitro. This review provides fresh ideas for the research and application of polysaccharide structure modification.

Funder

Jilin Science & Technology Development Plan

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/14/5416/pdf

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