Phenopyrrolizins A and B, Two Novel Pyrrolizine Alkaloids from Marine-Derived Actinomycetes Micromonospora sp. HU138-Reference-Cited by-同舟云学术

Phenopyrrolizins A and B, Two Novel Pyrrolizine Alkaloids from Marine-Derived Actinomycetes Micromonospora sp. HU138

Published:2023-11-20 Issue:22 Volume:28 Page:7672
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Zhang Hui¹²³^ORCID,Ren Xiaohan¹,Xu Haiju²,Qi Huan¹,Du Shihua³,Huang Jun¹⁴,Zhang Ji³,Wang Jidong¹

Affiliation:

1. Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, China

2. Key Laboratory of Horticultural Biotechnology of Taizhou, School of Agriculture and Bioengineering, Taizhou Vocational College of Science and Technology, Taizhou 318020, China

3. College of Plant Protection, Northeast Agricultural University, Harbin 150030, China

4. Zhejiang Makohs Biotech Co., Ltd., Taizhou 318000, China

Abstract

Two previously undescribed pyrrolizine alkaloids, named phenopyrrolizins A and B (1 and 2), were obtained from the fermentation broth of marine-derived Micromonospora sp. HU138. Their structures were established by extensive spectroscopic analysis, including 1D and 2D NMR spectra as well as HRESIMS data. The structure of 1 was confirmed by single-crystal diffraction analysis and its racemization mechanism was proposed. The antifungal activity assay showed that 2 could inhibit the mycelial growth of Botrytis cinerea with the inhibitory rates of 18.9% and 35.9% at 20 μg/disc and 40 μg/disc, respectively.

Funder

Key Research and Development Programs of Zhejiang Province

Zhejiang Provincial Natural Science Foundation of China

Natural Science Foundation of Huzhou City

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/22/7672/pdf

Reference34 articles.

1. Micromonospora: A prolific source of bioactive secondary metabolites with therapeutic potential;Yan;J. Med. Chem.,2022

2. Ribosome-binding and antimicrobial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida;Eyal;Nucleic Acids Res.,2021

3. Gong, T., Zhen, X., Li, X.L., Chen, J.J., Chen, T.J., Yang, J.L., and Zhu, P. (2018). Tetrocarcin Q, a new spirotetronate with a unique glycosyl group from a marine-derived actinomycete Micromonospora carbonacea LS276. Mar. Drugs, 16.

4. Micromonosporamide A with glutamine-dependent cytotoxicity from Micromonospora sp. MM609M-173N6: Isolation, stereochemical determination, and synthesis;Takeuchi;Org. Lett.,2021

5. Rakicidins G-I, cyclic depsipeptides from marine Micromonospora chalcea FIM 02–523;Chen;Tetrahedron,2018