Affiliation:
1. Department of Pharmaceutical Sciences, Università degli Studi di Milano, 20133 Milano, Italy
Abstract
Obesity and type 2 diabetes (T2DM) are major public health concerns associated with serious morbidity and increased mortality. Both obesity and T2DM are strongly associated with adiposopathy, a term that describes the pathophysiological changes of the adipose tissue. In this review, we have highlighted adipose tissue dysfunction as a major factor in the etiology of these conditions since it promotes chronic inflammation, dysregulated glucose homeostasis, and impaired adipogenesis, leading to the accumulation of ectopic fat and insulin resistance. This dysfunctional state can be effectively ameliorated by the loss of at least 15% of body weight, that is correlated with better glycemic control, decreased likelihood of cardiometabolic disease, and an improvement in overall quality of life. Weight loss can be achieved through lifestyle modifications (healthy diet, regular physical activity) and pharmacotherapy. In this review, we summarized different effective management strategies to address weight loss, such as bariatric surgery and several classes of drugs, namely metformin, GLP-1 receptor agonists, amylin analogs, and SGLT2 inhibitors. These drugs act by targeting various mechanisms involved in the pathophysiology of obesity and T2DM, and they have been shown to induce significant weight loss and improve glycemic control in obese individuals with T2DM.
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference93 articles.
1. (2023, February 20). IDF Diabetes Atlas|Tenth Edition. Available online: https://diabetesatlas.org/.
2. Conversion of Glycals into Vicinal-1,2-Diazides and 1,2-(or 2,1)-Azidoacetates Using Hypervalent Iodine Reagents and Me 3 SiN 3. Application in the Synthesis of N-Glycopeptides, Pseudo-Trisaccharides and an Iminosugar;Chennaiah;RSC Adv.,2017
3. Synthesis of (5,6 & 6,6)-Oxa-Oxa Annulated Sugars as Glycosidase Inhibitors from 2-Formyl Galactal Using Iodocyclization as a Key Step;Rajasekaran;Arkivoc,2022
4. Tseng, P., Ande, C., Moremen, K.W., and Crich, D. (2023). Influence of Side Chain Conformation on the Activity of Glycosidase Inhibitors. Angew. Chem. Int. Ed., 62.
5. Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as “Antidiabesity” Agents Based on Repurposing and Morphing of WB-4101;Artasensi;J. Med. Chem,2023
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