The Multifaceted S100B Protein: A Role in Obesity and Diabetes?-Reference-Cited by-同舟云学术

The Multifaceted S100B Protein: A Role in Obesity and Diabetes?

Published:2024-01-08 Issue:2 Volume:25 Page:776
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Michetti Fabrizio¹²³⁴^ORCID,Di Sante Gabriele⁵^ORCID,Clementi Maria Elisabetta¹^ORCID,Valeriani Federica⁶^ORCID,Mandarano Martina⁷^ORCID,Ria Francesco⁸^ORCID,Di Liddo Rosa⁹^ORCID,Rende Mario⁵,Romano Spica Vincenzo⁶^ORCID

Affiliation:

1. Istituto di Scienze e Tecnologie Chimiche “Giulio Natta” SCITEC-CNR, L.go F. Vito 1, 00168 Rome, Italy

2. Department of Neuroscience, Catholic University of the Sacred Heart, L.go F. Vito 1, 00168 Rome, Italy

3. Department of Medicine, LUM University, 70010 Casamassima, Italy

4. Genes, Via Venti Settembre 118, 00187 Roma, Italy

5. Department of Medicine and Surgery, Section of Human, Clinical and Forensic Anatomy, University of Perugia, 06132 Perugia, Italy

6. Department of Movement, Human and Health Sciences, University of Rome “Foro Italico”, 00135 Rome, Italy

7. Department of Medicine and Surgery, Section of Anatomic Pathology and Histology, Medical School, University of Perugia, 06132 Perugia, Italy

8. Department of Translational Medicine and Surgery, Section of General Pathology, Catholic University of the Sacred Heart, 00168 Rome, Italy

9. Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy

Abstract

The S100B protein is abundant in the nervous system, mainly in astrocytes, and is also present in other districts. Among these, the adipose tissue is a site of concentration for the protein. In the light of consistent research showing some associations between S100B and adipose tissue in the context of obesity, metabolic disorders, and diabetes, this review tunes the possible role of S100B in the pathogenic processes of these disorders, which are known to involve the adipose tissue. The reported data suggest a role for adipose S100B in obesity/diabetes processes, thus putatively re-proposing the role played by astrocytic S100B in neuroinflammatory/neurodegenerative processes.

Funder

Nando and Elsa Peretti Foundation

European Social Fund Plus Program

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-0067/25/2/776/pdf

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