Synthesis, X-ray Analysis, Biological Evaluation and Molecular Docking Study of New Thiazoline Derivatives-Reference-Cited by-同舟云学术

Synthesis, X-ray Analysis, Biological Evaluation and Molecular Docking Study of New Thiazoline Derivatives

Published:2019-04-26 Issue:9 Volume:24 Page:1654
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Mabkhot Yahia N.^ORCID,Algarni H.,Alsayari Abdulrhman,Bin Muhsinah Abdullatif,Kheder Nabila A.,Almarhoon Zainab M.^ORCID,Al-aizari Faiz A.

Abstract

A series of new thiazoline derivatives were synthesized. Structure analyses were accomplished employing 1H-NMR, 13C-NMR, X-ray and MS techniques. The in vitro antitumor activities were assessed against human hepatocellular carcinoma (HepG-2) and colorectal carcinoma (HCT-116) cell lines. The results revealed that the thiazolines 5b and 2c exhibited significant activity against the two cell lines. The in vitro antimicrobial screening showed that the thiazolines 2c, 5b and 5d showed promising inhibition activity against Salmonella sp. Additionally, the inhibition activity of thiazolines 2e and 5b against Escherichia coli was comparable to that of the reference compound gentamycin.

Funder

King Khalid University

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/24/9/1654/pdf

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