Synthesis, Characterization, and Biological Evaluation of Some Novel Pyrazolo[5,1-b]thiazole Derivatives as Potential Antimicrobial and Anticancer Agents-Reference-Cited by-同舟云学术

Synthesis, Characterization, and Biological Evaluation of Some Novel Pyrazolo[5,1-b]thiazole Derivatives as Potential Antimicrobial and Anticancer Agents

Published:2021-09-04 Issue:17 Volume:26 Page:5383
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Alsayari Abdulrhman^ORCID,Muhsinah Abdullatif Bin^ORCID,Asiri Yahya I.,Al-aizari Faiz A.,Kheder Nabila A.,Almarhoon Zainab M.^ORCID,Ghabbour Hazem A.^ORCID,Mabkhot Yahia N.

Abstract

The pharmacological activities of thiazole and pyrazole moieties as antimicrobial and anticancer agents have been thoroughly described in many literature reviews. In this study, a convenient synthesis of novel pyrazolo[5,1-b]thiazole-based heterocycles was carried out. The synthesized compounds were characterized by IR, 1H and 13C NMR spectroscopy and mass spectrometry. Some selected examples were screened and evaluated for their antimicrobial and anticancer activities and showed promising results. These products could serve as leading compounds in the future design of new drug molecules.

Funder

King Khalid University

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/26/17/5383/pdf

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