Phenolic Compounds of the Medicinal Plants in an Anthropogenically Transformed Environment

Author:

Vinogradova Natalya1,Vinogradova Elena2,Chaplygin Victor3,Mandzhieva Saglara3ORCID,Kumar Pradeep4,Rajput Vishnu D.3ORCID,Minkina Tatiana3ORCID,Seth Chandra Shekhar5ORCID,Burachevskaya Marina3ORCID,Lysenko Dionise6,Singh Rupesh Kumar7ORCID

Affiliation:

1. Department of Management, Economics of Pharmacy, Pharmacognosy and Pharmaceutical Technology, Federal State Budgetary Educational Institution of Higher Professional Education, M. Gorky Donetsk State Medical University, 283003 Donetsk, Russia

2. Laboratory of Dendrology of the Federal State Budgetary Scientific Institution “Donetsk Botanical Garden”, 283001 Donetsk, Russia

3. Academy of Biology and Biotechnology, Southern Federal University, 344006 Rostov-on-Don, Russia

4. Department of Botany, Banaras Hindu University, Varanasi 221005, India

5. Department of Botany, University of Delhi, New Delhi 110007, India

6. Faculty of Pharmacy, Saint Petersburg State Chemical and Pharmaceutical University, 197022 St. Petersburg, Russia

7. Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, 4704-553 Braga, Portugal

Abstract

In this article, the impact of an anthropogenically transformed environment on the content of pharmaceutically valuable biologically active compounds in medicinal plants is analyzed. The studied biologically active substances included phenolic compounds (flavonoids, anthocyanins, tannins, and phenolic acids). The number of transmissible forms of heavy metals (HMs), including cadmium, lead, and mercury, were discharged from factories that are present in the soil. Plants uptake these toxic metals from the soil. HM causes changes in the activity of the several enzymes such as phenylalanine ammonia lyase (PAL), chalcone synthase (CHS), chalcone isomerase (CHI) and other enzymes. These enzymes play an important role in biosynthesis of phenolic compounds in medicinal plants. It has been demonstrated that plant materials possess high antioxidant potential due to their high phenolic content. As a result, the present review discusses a thorough investigation of anthropogenically transformed environment effects on the quantity of pharmaceutically valuable phenolic compounds in medicinal plants.

Funder

Russian Science Foundation

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

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