Dysregulation of DNA Methylation and Epigenetic Clocks in Prostate Cancer among Puerto Rican Men

Author:

Berglund AndersORCID,Matta JaimeORCID,Encarnación-Medina JarlineORCID,Ortiz-Sanchéz CarmenORCID,Dutil Julie,Linares Raymond,Marcial Joshua,Abreu-Takemura Caren,Moreno Natasha,Putney Ryan,Chakrabarti RatnaORCID,Lin Hui-Yi,Yamoah Kosj,Osterman Carlos Diaz,Wang LiangORCID,Dhillon Jasreman,Kim Youngchul,Kim Seung Joon,Ruiz-Deya Gilberto,Park Jong Y.ORCID

Abstract

In 2021, approximately 248,530 new prostate cancer (PCa) cases are estimated in the United States. Hispanic/Latinos (H/L) are the second largest racial/ethnic group in the US. The objective of this study was to assess DNA methylation patterns between aggressive and indolent PCa along with ancestry proportions in 49 H/L men from Puerto Rico (PR). Prostate tumors were classified as aggressive (n = 17) and indolent (n = 32) based on the Gleason score. Genomic DNA samples were extracted by macro-dissection. DNA methylation patterns were assessed using the Illumina EPIC DNA methylation platform. We used ADMIXTURE to estimate global ancestry proportions. We identified 892 differentially methylated genes in prostate tumor tissues as compared with normal tissues. Based on an epigenetic clock model, we observed that the total number of stem cell divisions (TNSC) and stem cell division rate (SCDR) were significantly higher in tumor than adjacent normal tissues. Regarding PCa aggressiveness, 141 differentially methylated genes were identified. Ancestry proportions of PR men were estimated as African, European, and Indigenous American; these were 24.1%, 64.2%, and 11.7%, respectively. The identification of DNA methylation profiles associated with risk and aggressiveness of PCa in PR H/L men will shed light on potential mechanisms contributing to PCa disparities in PR population.

Funder

National Cancer Institute

Department of Defence

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry

Reference62 articles.

1. Cancer Facts & Figures 2021,2021

2. Cancer Stat Facts: Prostate Cancer,2018

3. Ethnic heterogeneity and prostate cancer mortality in Hispanic/Latino men: a population-based study

4. Cancer in Puerto Rico, 2006–2010;Tortolero-Luna,2013

5. DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3