Author:
Duerr Ralf,Crosse Keaton M.,Valero-Jimenez Ana M.,Dittmann Meike
Abstract
SARS-CoV-2 and HIV are zoonotic viruses that rapidly reached pandemic scale, causing global losses and fear. The COVID-19 and AIDS pandemics ignited massive efforts worldwide to develop antiviral strategies and characterize viral architectures, biological and immunological properties, and clinical outcomes. Although both viruses have a comparable appearance as enveloped viruses with positive-stranded RNA and envelope spikes mediating cellular entry, the entry process, downstream biological and immunological pathways, clinical outcomes, and disease courses are strikingly different. This review provides a systemic comparison of both viruses’ structural and functional characteristics, delineating their distinct strategies for efficient spread.
Funder
National Institute of Allergy and Infectious Diseases
Division of Intramural Research, National Institute of Allergy and Infectious Diseases
G. Harold and Leila Y. Mathers Charitable Foundation
NYU Grossman School of Medicine Startup funds
Subject
Virology,Microbiology (medical),Microbiology
Cited by
5 articles.
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