<i>De novo</i>design of a stapled peptide targeting SARS-CoV-2 spike protein receptor-binding domain-Reference-Cited by-同舟云学术

De novodesign of a stapled peptide targeting SARS-CoV-2 spike protein receptor-binding domain

Published:2023 Issue:9 Volume:14 Page:1722-1733
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Thakkar Ravindra¹^ORCID,Agarwal Dilip K.²^ORCID,Ranaweera Chathuranga B.³,Ishiguro Susumu¹,Conda-Sheridan Martin⁴^ORCID,Gaudreault Natasha N.⁵,Richt Juergen A.⁵,Tamura Masaaki¹,Comer Jeffrey¹^ORCID

Affiliation:

1. Department of Anatomy & Physiology, Kansas State University College of Veterinary Medicine, Manhattan, Kansas, USA

2. Department of Material Science and Engineering and NUANCE Center, Northwestern University, Evanston, Illinois, USA

3. Department of Medical Laboratory Sciences, General Sir John Kotelawala Defense University, Colombo, Sri Lanka

4. Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, USA

5. Department of Diagnostic Medicine & Pathobiology, Kansas State University College of Veterinary Medicine, Manhattan, Kansas, USA

Abstract

Binding configuration of ade novostapled peptide on SARS-CoV-2 spike protein, as predicted by molecular simulation. Stapled residues enhance peptide stability while interacting residues engage key amino acids on the protein receptor-binding domain.

Funder

National Cancer Institute

National Science Foundation

National Bio and Agro-defense Facility, Kansas State University

National Institute of Allergy and Infectious Diseases

U.S. Department of Agriculture

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00222E