Molecular Characterization of Dengue Virus Strains from the 2019–2020 Epidemic in Hanoi, Vietnam
-
Published:2023-05-11
Issue:5
Volume:11
Page:1267
-
ISSN:2076-2607
-
Container-title:Microorganisms
-
language:en
-
Short-container-title:Microorganisms
Author:
Phadungsombat Juthamas1ORCID, Vu Huong Thi Thu2, Nguyen Quynh Thi3, Nguyen Ha Thi Van2, Nguyen Ha Thi Nhu2, Dang Bich Thi2, Nakayama Emi E.1ORCID, Ishizaki Azumi3, Ichimura Hiroshi3, Shioda Tatsuo1ORCID, Pham Thach Ngoc2
Affiliation:
1. Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan 2. National Hospital for Tropical Disease, Hanoi 100000, Vietnam 3. Department of Viral infection and International Health, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Japan
Abstract
Dengue virus (DENV), which has circulated in Vietnam for several decades, has multiple serotypes and genotypes. A 2019 dengue outbreak resulted in a larger number of cases than any other outbreak. We conducted a molecular characterization using samples collected in 2019–2020 from dengue patients in Hanoi and nearby cities located in northern Vietnam. The circulating serotypes were DENV-1 (25%, n = 22) and DENV-2 (73%, n = 64). Phylogenetic analyses revealed that all DENV-1 (n = 13) were genotype I and clustered to local strains circulating during the previous outbreak in the 2017, whereas DENV-2 consisted of two genotypes: Asian-I (n = 5), related to local strains from 2006–2022, and cosmopolitan (n = 18), the predominant genotype in this epidemic. The current cosmopolitan virus was identified as having an Asian-Pacific lineage. The virus was closely related to strains in other recent outbreaks in Southeast Asian countries and China. Multiple introductions occurred in 2016–2017, which were possibly from maritime Southeast Asia (Indonesia, Singapore, and Malaysia), mainland Southeast Asia (Cambodia and Thailand), or China, rather than from an expansion of localized Vietnamese cosmopolitan strains that were previously detected in the 2000s. We also analyzed the genetic relationship between Vietnam’s cosmopolitan strain and recent global strains reported from Asia, Oceania, Africa, and South America. This analysis revealed that viruses of Asian-Pacific lineage are not restricted to Asia but have spread to Peru and Brazil in South America.
Funder
Japan Agency for Medical Research and Development Research Institute for Microbial Diseases, Osaka University
Subject
Virology,Microbiology (medical),Microbiology
Reference44 articles.
1. World Health Organization (2009). Dengue Guidelines for Diagnosis, Treatment, Prevention and Control: New Edition, World Health Organization. 2. World Health Organization (2023, April 03). Dengue and Severe Dengue. Available online: https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue. 3. Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: An historical perspective and role of antibody-dependent enhancement of infection;Guzman;Arch. Virol.,2013 4. Dengue—Quo tu et quo vadis?;Chen;Viruses,2011 5. Vu, T.T., Holmes, E.C., Duong, V., Nguyen, T.Q., Tran, T.H., Quail, M., Churcher, C., Parkhill, J., Cardosa, J., and Farrar, J. (2010). Emergence of the Asian 1 genotype of dengue virus serotype 2 in viet nam: In vivo fitness advantage and lineage replacement in South-East Asia. PLoS Negl. Trop. Dis., 4.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|