Memory T Cells Discrepancies in COVID-19 Patients-Reference-Cited by-同舟云学术

Memory T Cells Discrepancies in COVID-19 Patients

Published:2023-11-09 Issue:11 Volume:11 Page:2737
ISSN:2076-2607
Container-title:Microorganisms
language:en
Short-container-title:Microorganisms

Author:

Al Saihati Hajir A.¹^ORCID,Hussein Hosni A. M.²^ORCID,Thabet Ali A.³,Wardany Ahmed A.²,Mahmoud Sabry Y.⁴⁵^ORCID,Farrag Eman S.¹⁶,Mohamed Taha I. A.²,Fathy Samah M.⁷,Elnosary Mohamed E.⁸^ORCID,Sobhy Ali⁹^ORCID,Ahmed Abdelazeem E.⁹,El-Adly Ahmed M.²^ORCID,El-Shenawy Fareed S.²,Elsadek Asmaa A.¹⁰,Rayan Amal¹¹,Zahran Zeinab Albadry M.¹²,El-Badawy Omnia¹³,El-Naggar Mohamed G. M.¹⁴^ORCID,Afifi Magdy M.⁸^ORCID,Zahran Asmaa M.¹⁴

Affiliation:

1. Department of Clinical Laboratory Sciences, College of Applied Medical Science, University of Hafr Al Batin, P.O. Box 1803, Hafar Al Batin 31991, Saudi Arabia

2. Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Assiut 71524, Egypt

3. Department of Zoology, Faculty of Science, Al-Azhar University, Assiut 71524, Egypt

4. Biology Department, College of Sciences, University of Hafr Al-Batin, Hafr Al-Batin 31991, Saudi Arabia

5. Department of Microbiology, Sohag University, Sohag 82524, Egypt

6. Department of Microbiology, South Valley University, Qena 83523, Egypt

7. Department of Zoology, Faculty of Science, Fayoum University, Fayoum 63514, Egypt

8. Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City 11884, Egypt

9. Department of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Assiut 71524, Egypt

10. Department of Virology, Chest Hospital, Assiut 71514, Egypt

11. Department of Clinical Oncology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt

12. Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt

13. Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt

14. Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut 71515, Egypt

Abstract

The immune response implicated in Coronavirus disease 2019 (COVID-19) pathogenesis remains to be fully understood. The present study aimed to clarify the alterations in CD4+ and CD8+ memory T cells’ compartments in SARS-CoV-2-infected patients, with an emphasis on various comorbidities affecting COVID-19 patients. Peripheral blood samples were collected from 35 COVID-19 patients, 16 recovered individuals, and 25 healthy controls, and analyzed using flow cytometry. Significant alterations were detected in the percentage of CD8+ T cells and effector memory-expressing CD45RA CD8+ T cells (TEMRA) in COVID-19 patients compared to healthy controls. Interestingly, altered percentages of CD4+ T cells, CD8+ T cells, T effector (TEff), T naïve cells (TNs), T central memory (TCM), T effector memory (TEM), T stem cell memory (TSCM), and TEMRA T cells were significantly associated with the disease severity. Male patients had more CD8+ TSCMs and CD4+ TNs cells, while female patients had a significantly higher percentage of effector CD8+CD45RA+ T cells. Moreover, altered percentages of CD8+ TNs and memory CD8+CD45RO+ T cells were detected in diabetic and non-diabetic COVID-19 patients, respectively. In summary, this study identified alterations in memory T cells among COVID-19 patients, revealing a sex bias in the percentage of memory T cells. Moreover, COVID-19 severity and comorbidities have been linked to specific subsets of T memory cells which could be used as therapeutic, diagnostic, and protective targets for severe COVID-19.

Funder

the University of Hafr Al Batin

Publisher

MDPI AG

Subject

Virology,Microbiology (medical),Microbiology

Link

https://www.mdpi.com/2076-2607/11/11/2737/pdf

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