Affiliation:
1. Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Neuropsychiatric Diseases, Yunnan University of Chinese Medicine, Kunming 650500, China
2. School of Basic Medical Science, Yunnan University of Chinese Medicine, Kunming 650500, China
3. The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China
4. Department of Rehabilitation Medicine, The Affiliated Hospital of Yunnan University, Kunming 650021, China
Abstract
Ischemic stroke is a leading cause of death and disability in the world. At present, reperfusion therapy and neuroprotective therapy, as guidelines for identifying effective and adjuvant treatment methods, are limited by treatment time windows, drug bioavailability, and side effects. Nanomaterial-based drug delivery systems have the characteristics of extending half-life, increasing bioavailability, targeting drug delivery, controllable drug release, and low toxicity, thus being used in the treatment of ischemic stroke to increase the therapeutic effects of drugs. Therefore, this review provides a comprehensive overview of nanomaterial-based drug delivery systems from nanocarriers, targeting ligands and stimulus factors of drug release, aiming to find the best combination of nanomaterial-based drug delivery systems for ischemic stroke. Finally, future research areas on nanomaterial-based drug delivery systems in ischemic stroke and the implications of the current knowledge for the development of novel treatment for ischemic stroke were identified.
Funder
National Natural Science Foundation of China
Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province
Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Neuropsychiatric Diseases, Yunnan Provincial Department of Education
Scientific Research Projects for High-level Talents of Yunnan University of Chinese Medicine
Young Top-Notch Talent in 10,000 Talent Program of Yunnan Province
National Science and Technology Innovation 2030 Major Program
Yunnan Key Research and Development Program
Yunnan Province Fabao Gao Expert Workstation Construction Project
Yunnan Fundamental Research Projects
Scientific Research Fund of Yunnan Provincial Department of Education
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