A Review of 3D-Printing of Microneedles

Author:

Olowe Michael,Parupelli Santosh Kumar,Desai SalilORCID

Abstract

Microneedles are micron-sized devices that are used for the transdermal administration of a wide range of active pharmaceutics substances with minimally invasive pain. In the past decade, various additive manufacturing technologies have been used for the fabrication of microneedles; however, they have limitations due to material compatibility and bioavailability and are time-consuming and expensive processes. Additive manufacturing (AM), which is popularly known as 3D-printing, is an innovative technology that builds three-dimensional solid objects (3D). This article provides a comprehensive review of the different 3D-printing technologies that have the potential to revolutionize the manufacturing of microneedles. The application of 3D-printed microneedles in various fields, such as drug delivery, vaccine delivery, cosmetics, therapy, tissue engineering, and diagnostics, are presented. This review also enumerates the challenges that are posed by the 3D-printing technologies, including the manufacturing cost, which limits its viability for large-scale production, the compatibility of the microneedle-based materials with human cells, and concerns around the efficient administration of large dosages of loaded microneedles. Furthermore, the optimization of microneedle design parameters and features for the best printing outcomes is of paramount interest. The Food and Drug Administration (FDA) regulatory guidelines relating to the safe use of microneedle devices are outlined. Finally, this review delineates the implementation of futuristic technologies, such as artificial intelligence algorithms, for 3D-printed microneedles and 4D-printing capabilities.

Funder

National Science Foundation

Center of Excellence in Product Design and Advanced Manufacturing at North Carolina A&T State University

Publisher

MDPI AG

Subject

Pharmaceutical Science

Reference196 articles.

1. Aldawood, F.K., Desai, S., and Chang, S. (June, January 30). Additive Manufacturing of Compensator Devices for Radiation Therapy. Proceedings of the 2020 IISE Annual Conference, New Orleans, LA, USA.

2. Understanding Hybrid Additive Manufacturing of Functional Devices;Parupelli;Am. J. Eng. Appl. Sci.,2017

3. 3D Printing of Porous Scaffolds for Medical Applications;Aljohani;Am. J. Eng. Appl. Sci.,2018

4. Investigating Rapid Thermoform Tooling Via Additive Manufacturing (3d Printing);Haeberle;Am. J. Appl. Sci.,2019

5. Desai, S., and Parupelli, S. (2022). Maynard’s Industrial and Systems Engineering Handbook, Springer International Publishing. [6th ed.].

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3