Hybrid Pectin-Liposome Formulation against Multi-Resistant Bacterial Strains

Author:

Ribeiro Lígia Nunes de MoraisORCID,de Paula EneidaORCID,Rossi Daise Aparecida,Monteiro Guilherme Paz,Júnior Edson Campos Valadares,Silva Rogério Reis,Franco Rodrigo Rodrigues,Espíndola Foued SalmenORCID,Goulart Luiz RicardoORCID,Fonseca Belchiolina BeatrizORCID

Abstract

This work describes the development of a gastroresistant antimicrobial formulation composed of two carriers, pectin and liposomes, intended to improve the efficiency of norfloxacin (NOR) against multi-resistant bacterial strains. The formulations showed physicochemical stability for 180 days (4 °C) in terms of size, polydispersity, and zeta potential of the vesicles, prolonging the in vitro release of NOR for 11 h. The hybrid nanocarriers improved the in vitro antimicrobial activity against different multidrug-resistant bacterial strains, such as Salmonella sp., Pseudomonasaeruginosa, E. coli and Campylobacterjejuni, in comparison to commercial NOR and liposomal suspensions. The in vivo toxicity assay in chicken embryos revealed that the hybrid systems were not toxic in any of the different parameters analyzed, a result also corroborated by the analyses of biochemical biomarkers of the chicken-embryos liver function.

Publisher

MDPI AG

Subject

Pharmaceutical Science

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