Abstract
Selenium-containing agents are more and more considered as an innovative potential treatment option for cancer. Light is shed not only on the considerable advancements made in understanding the complex biology and chemistry related to selenium-containing small molecules but also on Se-nanoparticles. Numerous Se-containing agents have been widely investigated in recent years in cancer therapy in relation to tumour development and dissemination, drug delivery, multidrug resistance (MDR) and immune system-related (anti)cancer effects. Despite numerous efforts, Se-agents apart from selenocysteine and selenomethionine have not yet reached clinical trials for cancer therapy. The purpose of this review is to provide a concise critical overview of the current state of the art in the development of highly potent target-specific Se-containing agents.
Funder
Sapienza University of Rome SEED PNR 2021
Kohr Aerospace GmbH
FSE REACT-EU
Enrico and Enrica Sovena
Reference242 articles.
1. Greenwood, N.N., and Earnshaw, A. (2012). Chemistry of the Elements, Elsevier.
2. Lenardão, E.J., Santi, C., and Sancineto, L. (2018). New Frontiers in Organoselenium Compounds, Springer International Publishing.
3. The two faces of selenium—Can selenophobia be cured?;Frost;CRC Crit. Rev. Toxicol.,1972
4. The innovative potential of selenium-containing agents for fighting cancer and viral infections;Ali;Drug Discov. Today,2021
5. Santi, C., and Bagnoli, L. (2017). Celebrating Two Centuries of Research in Selenium Chemistry: State of the Art and New Prospective. Molecules, 22.
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