Thia‐ and Seleno‐Michael Reactions for the Synthesis of Carbonic Anhydrases Inhibitors-Reference-Cited by-同舟云学术

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Thia‐ and Seleno‐Michael Reactions for the Synthesis of Carbonic Anhydrases Inhibitors

Published:2024-08-08 Issue: Volume: Page:
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Angeli Andrea¹,Occhini Alessio²,Renzi Gioele¹,Capperucci Antonella²,Ferraroni Marta²,Tanini Damiano²^ORCID,Supuran Claudiu T.¹

Affiliation:

1. NEUROFARBA Deptartment Sezione di Scienze Farmaceutiche University of Florence Via Ugo Schiff 6, Sesto Fiorentino 50019 Florence Italy

2. Department of Chemistry “Ugo Schiff” (DICUS) University of Florence Via della Lastruccia 3–13, Sesto Fiorentino I-50019 Florence Italy

Abstract

AbstractNovel chalcogen‐containing amides and esters bearing the benzenesulfonamide moiety have been synthesised upon nucleophilic conjugate addition of thiols and selenols to suitable electron‐deficient alkenes. The activity of the synthesised compounds as Carbonic Anhydrases inhibitors has been investigated in vitro and the inhibition mechanism has been elucidated by X‐rays studies.

Publisher

Wiley

Reference71 articles.

1. Structure and function of carbonic anhydrases

2. How many carbonic anhydrase inhibition mechanisms exist?

3. Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 – 2013)

4. Glaucoma and the Applications of Carbonic Anhydrase Inhibitors

5. Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment

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