Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review

Author:

Viegas Cláudia1234ORCID,Patrício Ana B.34,Prata João M.34ORCID,Nadhman Akhtar5,Chintamaneni Pavan Kumar6ORCID,Fonte Pedro1347ORCID

Affiliation:

1. Center for Marine Sciences (CCMar), University of Algarve, Gambelas Campus, 8005-139 Faro, Portugal

2. Faculty of Medicine and Biomedical Sciences (FMCB), University of Algarve, Gambelas Campus, 8005-139 Faro, Portugal

3. iBB—Institute for Bioengineering and Biosciences, Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal

4. Associate Laboratory i4HB—Institute for Health and Bioeconomy, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal

5. Institute of Integrative Biosciences, CECOS University, Hayatabad, Peshawar 25000, Pakistan

6. Department of Pharmaceutics, GITAM School of Pharmacy, GITAM-Hyderabad Campus, Hyderabad 502329, Telangana, India

7. Department of Chemistry and Pharmacy, Faculty of Sciences and Technology, University of Algarve, Gambelas Campus, 8005-139 Faro, Portugal

Abstract

Solid–lipid nanoparticles and nanostructured lipid carriers are delivery systems for the delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures. These nanocarriers may enhance the solubility and permeability of drugs, increase their bioavailability, and extend the residence time in the body, combining low toxicity with a targeted delivery. Nanostructured lipid carriers are the second generation of lipid nanoparticles differing from solid lipid nanoparticles in their composition matrix. The use of a liquid lipid together with a solid lipid in nanostructured lipid carrier allows it to load a higher amount of drug, enhance drug release properties, and increase its stability. Therefore, a direct comparison between solid lipid nanoparticles and nanostructured lipid carriers is needed. This review aims to describe solid lipid nanoparticles and nanostructured lipid carriers as drug delivery systems, comparing both, while systematically elucidating their production methodologies, physicochemical characterization, and in vitro and in vivo performance. In addition, the toxicity concerns of these systems are focused on.

Funder

Fundação para a Ciência e a Tecnologia

Research Unit Center for Marine Sciences—CCMAR

Research Unit Institute for Bioengineering and Biosciences—iBB

Associate Laboratory Institute for Health and Bioeconomy—i4HB

FCT

Publisher

MDPI AG

Subject

Pharmaceutical Science

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