Electrospun Nanofibers for Dura Mater Regeneration: A Mini Review on Current Progress

Author:

Pant Bishweshwar123ORCID,Park Mira123ORCID,Kim Allison4ORCID

Affiliation:

1. Carbon Composite Energy Nanomaterials Research Center, Woosuk University, Wanju 55338, Republic of Korea

2. Woosuk Institute of Smart Convergence Life Care (WSCLC), Woosuk University, Wanju 55338, Republic of Korea

3. Department of Automotive Engineering, Woosuk University, Wanju 55338, Republic of Korea

4. Department of Healthcare Management, Woosong University, Daejon 34606, Republic of Korea

Abstract

Dural defects are a common problem in neurosurgical procedures and should be repaired to avoid complications such as cerebrospinal fluid leakage, brain swelling, epilepsy, intracranial infection, and so on. Various types of dural substitutes have been prepared and used for the treatment of dural defects. In recent years, electrospun nanofibers have been applied for various biomedical applications, including dural regeneration, due to their interesting properties such as a large surface area to volume ratio, porosity, superior mechanical properties, ease of surface modification, and, most importantly, similarity with the extracellular matrix (ECM). Despite continuous efforts, the development of suitable dura mater substrates has had limited success. This review summarizes the investigation and development of electrospun nanofibers with particular emphasis on dura mater regeneration. The objective of this mini-review article is to give readers a quick overview of the recent advances in electrospinning for dura mater repair.

Funder

Carbon-Agricultural Livestock Industry Project of Jeollabuk-do, South Korea

National Research Foundation of Korea

Publisher

MDPI AG

Subject

Pharmaceutical Science

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