Peptide-Based Bioconjugates and Therapeutics for Targeted Anticancer Therapy

Author:

Yang Seong-Bin,Banik NipaORCID,Han Bomin,Lee Dong-Nyeong,Park JoohoORCID

Abstract

With rapidly growing knowledge in bioinformatics related to peptides and proteins, amino acid-based drug-design strategies have recently gained importance in pharmaceutics. In the past, peptide-based biomedicines were not widely used due to the associated severe physiological problems, such as low selectivity and rapid degradation in biological systems. However, various interesting peptide-based therapeutics combined with drug-delivery systems have recently emerged. Many of these candidates have been developed for anticancer therapy that requires precisely targeted effects and low toxicity. These research trends have become more diverse and complex owing to nanomedicine and antibody–drug conjugates (ADC), showing excellent therapeutic efficacy. Various newly developed peptide–drug conjugates (PDC), peptide-based nanoparticles, and prodrugs could represent a promising therapeutic strategy for patients. In this review, we provide valuable insights into rational drug design and development for future pharmaceutics.

Funder

Regional Innovation Strategy

Publisher

MDPI AG

Subject

Pharmaceutical Science

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