Probiotics in Wound Healing

Author:

Bădăluță Valentina Alexandra12ORCID,Curuțiu Carmen12ORCID,Dițu Lia Mara12,Holban Alina Maria12,Lazăr Veronica12

Affiliation:

1. Department of Microbiology, Faculty of Biology, University of Bucharest, 030018 București, Romania

2. Research Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, Romania

Abstract

Wound infections caused by opportunistic bacteria promote persistent infection and represent the main cause of delayed healing. Probiotics are acknowledged for their beneficial effects on the human body and could be utilized in the management of various diseases. They also possess the capacity to accelerate wound healing, due to their remarkable anti-pathogenic, antibiofilm, and immunomodulatory effects. Oral and topical probiotic formulations have shown promising openings in the field of dermatology, and there are various in vitro and in vivo models focusing on their healing mechanisms. Wound dressings embedded with prebiotics and probiotics are now prime candidates for designing wound healing therapeutic approaches to combat infections and to promote the healing process. The aim of this review is to conduct an extensive scientific literature review regarding the efficacy of oral and topical probiotics in wound management, as well as the potential of wound dressing embedding pre- and probiotics in stimulating the wound healing process.

Publisher

MDPI AG

Reference83 articles.

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