Affiliation:
1. Department of Molecular Medicine and Surgery, Karolinska Institute, 17176 Stockholm, Sweden
2. Center for Diabetes, Academic Specialist Center, 11365 Stockholm, Sweden
Abstract
The aim of this study was to assess the effect of four isocaloric meals with different macronutrient compositions on postprandial blood glucose, lipids, and glucagon in adults with type 1 diabetes (T1D). Seventeen subjects tested four isocaloric meals in a randomized crossover design. The meal compositions were as follows: high-carbohydrate (HC); high-carbohydrate with extra fiber (HC-fiber); low-carbohydrate high-protein (HP); and low-carbohydrate high-fat (HF). Blood glucose and lipid measurements were collected up to 4 h and glucagon up to 3 h postprandially. Mean postprandial glucose excursions were lower after the HP compared to the HC (p = 0.036) and HC-fiber meals (p = 0.002). There were no differences in mean glucose excursions after the HF meal compared to the HC and HP meals. The HF meal resulted in higher triglyceride excursions compared to the HP meal (p < 0.001) but not compared to the HC or HC-fiber meals. Glucagon excursions were higher at 180 min after the HP meal compared to the HC and HF meals. In conclusion, the low-carbohydrate HP meal showed the most favorable glycemic and metabolic effects during a 4 h postprandial period in subjects with T1D.
Funder
Ronald Adolfsson
Berth Von Kantzow Foundation
Family Erling-Persson Foundations
Skandia Foundation
Margareta Nilsson’s Foundation
Stockholm County Research Council
Stockholm Regional Research Foundation
Swedish Society of Medicine
Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse
Subject
Food Science,Nutrition and Dietetics
Cited by
2 articles.
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