The Effectiveness of Supplementation with Key Vitamins, Minerals, Antioxidants and Specific Nutritional Supplements in COPD—A Review

Author:

Fekete Mónika1ORCID,Csípő Tamás1ORCID,Fazekas-Pongor Vince1,Fehér Ágnes1,Szarvas Zsófia1ORCID,Kaposvári Csilla1,Horváth Krisztián1,Lehoczki Andrea2,Tarantini Stefano345ORCID,Varga János Tamás6ORCID

Affiliation:

1. Department of Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary

2. Department of Haematology and Stem Cell Transplantation, National Institute for Haematology and Infectious Diseases, South Pest Central Hospital, 1097 Budapest, Hungary

3. Department of Neurosurgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA

4. Department of Health Promotion Sciences, College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA

5. Peggy and Charles Stephenson Oklahoma Cancer Center, Oklahoma City, OK 73104, USA

6. Department of Pulmonology, Semmelweis University, 1083 Budapest, Hungary

Abstract

Currently, an increasing amount of evidence supports the notion that vitamins C, D and E, carotenoids, and omega-3 fatty acids may protect against the progression of chronic respiratory diseases. Although chronic obstructive pulmonary disease (COPD) primarily affects the lung, it is often accompanied by extrapulmonary manifestations such as weight loss and malnutrition, skeletal muscle dysfunction, and an excess of harmful oxidants, which can lead to a decline in quality of life and possible death. Recently, the role of various vitamins, minerals, and antioxidants in mitigating the effects of environmental pollution and smoking has received significant attention. Therefore, this review evaluates the most relevant and up-to-date evidence on this topic. We conducted a literature review between 15 May 2018 and 15 May 2023, using the electronic database PubMed. Our search keywords included COPD, chronic obstructive pulmonary disease, FEV1, supplementation: vitamin A, vitamin D, vitamin E, vitamin C, vitamin B, omega-3, minerals, antioxidants, specific nutrient supplementations, clinical trials, and randomized controlled trials (RCTs). We focused on studies that measured the serum levels of vitamins, as these are a more objective measure than patient self-reports. Our findings suggest that the role of appropriate dietary supplements needs to be reconsidered for individuals who are predisposed to or at risk of these conditions.

Funder

National Research, Development and Innovation Fund

Ministry of Innovation and Technology

European University for Well-Being (EUniWell) program

National Institute on Aging

American Heart Association

NIA-supported Geroscience Training Program in Oklahoma

NIA-supported Oklahoma Nathan Shock Center

NIGMS-supported Center of Biomedical Research Excellence

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

Reference128 articles.

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