Abstract
Platelets are active key players in haemostasis. Qualitative platelet dysfunctions result in thrombocytopathies variously characterized by defects of their adhesive and procoagulant activation endpoints. In this review, we summarize the traditional platelet defects in adhesion, secretion, and aggregation. In addition, we review the current knowledge about procoagulant platelets, focusing on their role in bleeding or thrombotic pathologies and their pharmaceutical modulation. Procoagulant activity is an important feature of platelet activation, which should be specifically evaluated during the investigation of a suspected thrombocytopathy.
Funder
Fondation Dr Henri Dubois-Ferrière Dinu Lipatti
Novartis Stiftung für Medizinisch-Biologische Forschung
Schweizerische Herzstiftung
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
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