The Application of Intelligent Data Models for Dementia Classification

Abstract

Background and Objective: Dementia is a broad term for a complex range of conditions that affect the brain, such as Alzheimer’s disease (AD). Dementia affects a lot of people in the elderly community, hence there is a huge demand to better understand this condition by using cost effective and quick methods, such as neuropsychological tests, since pathological assessments are invasive and demand expensive resources. One of the promising initiatives that deals with dementia and Mild Cognitive Impairment (MCI) is the Alzheimer’s Disease Neuroimaging Initiative (ADNI), which includes cognitive tests, such as Clinical Dementia Rating (CDR) scores. The aim of this research is to investigate non-invasive dementia indicators, such as cognitive features, that are typically diagnosed by clinical assessment within ADNI’s data to understand their effect on dementia. Methods: To achieve the aim, machine learning techniques have been utilized to classify patients into Cognitively Normal (CN), MCI, or having dementia, based on the sum of CDR scores (CDR-SB) besides demographic variables. Particularly, the performance of Support Vector Machine (SVM), K-nearest neighbors (KNN), Decision Trees (C4.5), Probabilistic Naïve Bayes (NB), and Rule Induction (RIPPER) is measured with respect to different evaluation measures, including specificity, sensitivity, and harmonic mean (F-measure), among others, on a large number of cases and controls from the ADNI dataset. Results: The results indicate competitive performance when classifying subjects from the baseline selected variables using machine learning technology. Though we observed fairly good results across all machine learning algorithms utilized, there was still variation in the performance ability, indicating that some algorithms, such as NB and C4.5, are better suited to the task of classifying dementia status based on our baseline data. Conclusions: Using cognitive tests, such as CDR-SB scores, with demographic attributes to pinpoint to dementia using machine learning can be seen a less invasive approach that could be good for clinical use to aid in the diagnosis of dementia. This study gives an indication that a comprehensive assessment tool, such as CDR, may be adequate in assessing and assigning a dementia class to patients, upon their visit, in order to speed further clinical procedures.