The Mixture of Gastrodia elata and Glycyrrhiza uralensis Attenuates Scopolamine-Induced Cognitive Disorder

Abstract

Background: Cognitive disorders are symptoms of degenerative neuronal diseases such as Alzheimer’s disease (AD). This study evaluated the effects of a mixture of Gastrodiae elata (GE) and Glycyrrhizae uralensis (GU) (GGW) on scopolamine-treated cognitive function disorders in vivo. Methods: To induce memory impairment and cognitive disorder, C57BL/6 mice were intraperitoneally administered scopolamine. In the experimental period, the Y-maze, passive avoidance, and water maze tests were carried out to measure the ameliorative effect of GGW on cognitive function disorder. The expression of amyloid-β (Aβ), brain-derived neurotrophic factor (BDNF), and acetylcholinesterase (AChE) in the hippocampal tissues were measured. In addition, to assess the effect of GGW on brain tissue, tissues were stained using hematoxylin and eosin (H&E). Results: GGW treatment improved latencies in the Y-maze, water maze, and passive avoidance tests compared with scopolamine treatment alone. GGW administration downregulated Aβ and AChE expression. In addition, BDNF expression was upregulated by GGW administration. Conclusion: These results suggest that GGW ameliorates impaired cognitive function in a scopolamine-induced mouse model. In addition, GGW could control the pathway of scopolamine-induced cognitive disorders by regulating Aβ, AChE, and BDNF. These results suggest that GGW could be used as a treatment agent for cognitive dysfunction.