Author:
Tycova Anna,Kleparnik Karel,Foret Frantisek
Abstract
Elimination of massive aggregation of nanoparticles in the sample of high ionic strength is a prerequisite for the sensitive analysis through a surface-enhanced Raman spectrometry (SERS). We present a system of silver colloid modification composed of two thiolated modifiers (3-mercaptopropionic acid and thiolated polyethylene glycol) both creating a strong Ag-S bond. At their optimal molar ratio, the polymer acts as a steric barrier preventing direct nanoparticle–nanoparticle interaction, while the low-molecular organic acid creates areas accessible for the analyte molecules. Thus, this approach is an excellent tool for sustaining both the colloidal stability and SERS sensitivity. The functionality of the system was demonstrated on the SERS analysis of myoglobin from a saline solution. The favorable creation of hot spots was achieved by laser-induced sintering.
Funder
Ministry of Education, Youths and Sports of the Czech Republic
Subject
General Materials Science,General Chemical Engineering
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献